SAPA-NE 2023 Bimonthly Seminar - May
Sat, May 06
|Free Zoom Webinar
A Hybrid Design for Dose-Finding Oncology Clinical Trials


Event Time
May 06, 2023, 11:00 AM – 12:00 PM EDT
Free Zoom Webinar
About the Event
SAPA-NE 2023 Bimonthly Seminar
A Hybrid Design for Dose-Finding Oncology Clinical Trials
Abstract
Identifying the maximum tolerated dose (MTD) and recommending a Phase II dose for an investigational treatment is crucial in cancer drug development. A suboptimal dose often leads to a failed late-stage trial, while an overly toxic dose causes harm to patients. There is a very rich literature on trial designs for dose-finding oncology clinical trials. We pro[1]pose a novel hybrid design that maximizes the merits and minimizes the limitations of the existing designs. Building on two existing dose-finding designs: a model-assisted design (the modified toxicity probability interval) and a dose-toxicity model-based design, a hybrid design of the modified toxicity probability interval design and a dose-toxicity model such as the logistic regression model is proposed, incorporating optimal properties from these existing approaches. The performance of the hybrid design was tested in a real trial example and through simulation…
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